- 2004 - present
Aristotle University of Thessaloniki, Thessaloniki, Greece
- 1995 -2004
University of Crete, Heraklion, Greece
- 1988 -1995
Massachusetts Institute of Technology, Cambridge, MA, U.S.A.
- 1992 -1993
N. England Medical Center/Tufts University, Boston, MA, U.S.A.
- 1983 -1987
University of Michigan, Ann Arbor, MI, U.S.A.
Max-Planck Institute of Radiation Chemistry
Mlheim an der Ruhr, Germany.
Inorganic-organic hybrid surface-modified (dendrimers, liposomes and silica) and magnetic nanoparticles capable of transport, selective and specific delivery of molecular probes to neuro-loci in the brain for imaging. Bioinorganic vanadium, titanium and zinc compounds with physiological and biomimetic substrates, as potential pharmaceuticals of anticarcinogenic and insulin mimetic activity. Synthetic, spectroscopic, magnetic, structural and biological studies of vanadium and zinc species bearing physiological and biomimetic hydroxycarboxylic acids. Controlled release of synthetic or naturally encountered molecules from (macro)molecular cages relevant to metallodrug absorption and bio-activity processes. (Multi)functional materials with applications (sensors) in Biomedical Engineering diagnostic medicine and (nano)technology.
Design and development of technological approaches linked to metal-catalyzed oxidative damage of biological tissues. Oxidative stress in neurodegeneration. Development of selective chemosensors of essential and non-essential metal ions in relation to clinically pathological conditions in neurodegenerative diseases. Diagnostic molecular biomarkers in Mild Cognitive Impairment and Alzheimer˘s dementia.
Carcinogenic metal ions in the transcriptional activation of signal transducing Há-Ras genes through DNA minisatellites in the human genome. Interactions of heavy metal and biotoxic metal ions with DNA minisatellites and consequences in the metallobiological pathways leading to carcinogenesis. Development of biomarker technologies correlating biotoxic metal ion-DNA minisatellite interactions with diagnosis (or even prognosis) of aberrant processes in signal transduction pathways.
Biotoxic metal ions in the pathogenesis of neurodegenerative diseases (Alzheimer, etc.) and neoplasias (carcinogenesis). Linkage of soluble inorganic complex species (environmental metallotoxins) with processes involving interactions of biotoxic metal ions with defined cellular targets, structural speciation, bioavailability and etiopathogenetic biochemical reactivity. Development of (nano)molecular sensors and diagnostic tools for the immediate detection of early neurodegenerative events. Correlation of toxicity-neurodegeneration at the molecular level.
Development of metallofluorimetric chemosensor technology for the selective detection and quantitative determination of metallotoxins and metallotoxin pollutants in environmental and biological fluids through the use of HPLC-PCD chromatography. Monitoring applications in environmental protection and metal ionic homeostasis at the cellular level.
Surface-modified nanoparticles (dendrimers, liposomes and silica) in the selective separation and recovery of toxic and heavy metal ions from water resources in the environment. Fundamental structure-function correlations in nanoparticle physicochemical nature and reactivity supporting the development of technology management of metallotoxins in the environment.
Synthesis of inorganic and inorganic-organic hybrid materials at low temperatures with specific chemical catalytic, physical structural and magnetic properties. Emphasis is given to the synthesis of single molecule magnets and chains as advanced materials at the nanotechnological level.
Natural antioxidants and pro-oxidant metal ionic materials in human nutrition. Mechanisms of pro-oxidant metals and antioxidant behavior of natural products through the use of experimental models in human physiology.
Design, synthesis, spectroscopic and structural characterization of biomimetic inorganic complexes as minimal representations of the active site metalloclusters in metalloenzymes. Development of catalytic processes involving small molecule activation through the employment of low molecular mass metal-ionic materials.
Durability performance of Portland limestone cement mortar containing butyl and zinc stearate admixtures A. Malakopoulos, M. Chatzigeorgiou, N. Boukos, A. Salifoglou Materials and Structures 2021, 54, 60
Biomimetic activity of soluble, well-defined, aqueous Ti(IV)-citrate species toward adipogenesis. An in vitro study O. Tsave, A. Salifoglou J. Inorganic Biochemistry 2021, 214, 111290
Unraveling the blood transcriptome after real-life exposure of Wistar-rats to PM2.5, PM1 and water-soluble metals in the ambient air. I. S. Frydas, M. Kermenidou, O. Tsave, A. Salifoglou, D. A. Sarigiannis Toxicology Reports 2020, 7, 1469-1479
Modified magnetic core-shell mesoporous silica nano-formulations with encapsulated quercetin exhibit anti-amyloid and antioxidant activity E. Halevas, B. Mavroidi, C. M. Nday, J. Tang, G. C. Smith, N. Boukos, G. Litsardakis, M. Pelecanou, A. Salifoglou J. Inorganic Biochemistry 2020, 213, 111271
Temperature-Sensitive Structural Speciation of Cobalt-Iminodialcohol-(N,N?-Aromatic Chelator) Systems: Lattice Architecture and Spectrochemical Properties. S. Matsia, M. Menelaou, A. Hatzidimitriou, V. Tangoulis, N. Lalioti, N. Ioannidis, L. Blomer, B. Kersting, A. Salifoglou Eur. J. Inorg. Chem., 2020, 2919-2940
Piperazine core-containing Schiff ligands define chemical reactivity toward divalent metal ions C. Cretu, L. Cseh, R. Tudose, A. Bora, S. Matsia, A. Hatzidimitriou, O. Costisor, A. Salifoglou Inorganica Chimica Acta, 2019, 492, 249-261.
Binary-ternary Cd(II)-(hydroxycarboxylic acid)-(aromatic chelator) systems exhibit in vitro cytotoxic selectivity in a tissue-specific manner O.Tsave, C.Iordanidou, C.Gabriel, A. Hatzidimitriou, A.Salifoglou J. Inorganic Biochemistry, 2019, 195, 201-215.
Synthesis and encapsulation of V(IV,V) compounds in silica nanoparticles targeting development of antioxidant and antiradical nanomaterials. E. Halevas, C.M. Nday, D. Eleftheriadou, G. Jackson, V. Psycharis, C.P. Raptopoulou, D.G. Reid, K. Ypsilantis, G. Litsardakis, A. Salifoglou J. Inorganic Biochemistry, 2019, 194, 180-199.
In-depth synthetic, physicochemical and in vitro biological investigation of a new ternary V(IV) antioxidant material based on curcumin E. Halevas, T.A. Papadopoulos, C.H. Swanson, G.C. Smith, A. Hatzidimitriou, G. Katsipis, A. Pantazaki, I. Sanakis, G. Mitrikas, K. Ypsilantis, G. Litsardakis, A. Salifoglou J. Inorganic Biochemistry, 2019, 191, 94-111.
Phagocytosis and Cytotoxicity Analysis of Thioflavin-T Doped Silica-Coated Superparamagnetic Iron Oxide Nanoparticles Bound to Amyloid Beta 1-42 A.C. Tsolakis, E. Gounari, E. Halevas, G.G. Koliakos, A. Salifoglou, G. Litsardakis IEEE Magnetics Letters, Biomagnetics, 2018, 9, 1502505.
Comparative assessment of metal-specific adipogenic activity in zinc and vanadium-citrates through associated gene expression O. Tsave, M.P. Yavropoulou, M. Kafantari, C. Gabriel, J.G. Yovos, A. Salifoglou J. Inorganic Biochemistry, 2018, 186, 217-227.
Metallodrugs in Targeted Cancer Therapeutics. Aiming at Chemoresistance-related Patterns and Immunosuppressive Tumor Networks S. Petanidis, E. Kioseoglou, A. Salifoglou Current Medicinal Chemistry, 2018, 25, 1-17.
Synthetic investigation of binary-ternary Cr(III)-hydroxycarboxylic acid-aromatic chelator systems. Structure-specific influence on adipogenic biomarkers linked to insulin mimesis O. Tsave, C. Gabriel, M. Kafantari, M.P. Yavropoulou, J.G. Yovos, C.P. Raptopoulou,V. Psycharis, A. Terzis, C. Mateescu, A. Salifoglou J. Inorganic Biochemistry, 2018, 184, 50-68.
Synthetic exploration of the binary cadmium-quinic acid system linked to in vitro cytotoxicity and chelation cytoprotection investigation C. Iordanidou, O. Tsave, C. Gabriel, A. Hatzidimitriou, A. Salifoglou Inorganic Chimica Acta, 2018, 482, 364-374.
A systematic synthetic study of the aqueous chemistry of binary boron-hydroxycarboxylic acids systems. Boron structural speciation correlation to lattice structure and photoactivity. S. Matsia, O. Tsave, A. Hatzidimitriou, C. Gabriel, M. Bertmer, A. Salifoglou European Journal of Inorganic Chemistry, 2018, 1284-1301.
In vitro structure-specific Zn(II)-induced adipogenesis and structure-function bioreactivity correlations. E. Halevas, O. Tsave, M. Yavropoulou, J.G. Yovos, A. Hatzidimitriou, V. Psycharis, A. Salifoglou J. Inorganic Biochemistry, 2017, 177, 228-246.
Synthetic endeavors on cadmium species bearing glycolate and aromatic chelators with structure-specific biotoxic correlations in vitro. C. Iordanidou, O. Tsave, C. Gabriel, A. Hatzidimitriou, M.P. Yavropoulou, C. Mateescu, A. Salifoglou J. Inorganic Biochemistry, 2017, 176, 38-52.